VDO of Doxycycline as an Agent for "Wound Chemotherapy"
Doxycycline as an Agent for "Wound Chemotherapy" Video Clips. Duration : 3.25 Mins.We had a good read. For the benefit of yourself. Be sure to read to the end. I want you to get good knowledge from What Is Health Care Management. Essential Medical Textbooks: astore.amazon.com Popular Running Shoes: astore.amazon.com Doxycycline is a semi-synthetic tetracycline compound. Classically, this drug is used in podiatry and wound care for its properties of antibiosis and antisepsis. There have, however, been some investigations of doxycycline and other chemically modified tetracycline species (CMTS), which demonstrate its potential as an inflammatory modulator. These qualities may prove useful within a wound environment. This is particularly so, as an inhibitor of nitric oxide (NO) production, matrix metalloprotease (MMP) activity, and tissue necrosis factor alpha converting enzyme (TACE). MMP activity has been identified as a key player in the environment of chronic wounds as well. Although MMP's are part of the normal breakdown and remodeling of tissues within the human body, non-healing ulcers are particularly less governed by regulatory mechanisms and therefore see an overabundance of MMP activity, and consequently lead to the persistence of inflammation and degradation of the epithelial matrix in situ. The chemical structure of doxycycline has been investigated, and demonstrates satisfactory results as an inhibitor of such zinc catalyzed protease activity. By inhibiting the activity of various MMP species in a wound bed, the breakdown of wound matrix may be prevented. Similar to MMP inhibition, TACE (otherwise known as ADAM17) is a member of the same metalloprotease superfamily and thus inhibition ...
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